MDxHealth fait le point sur ses activités - mdxhealth (2024)

· Albala D, Kemeter MJ, Febbo PG, Lu R, John V, Stoy D et al. Health economic impact and prospective clinical utility of Oncotype DX Genomic Prostate Score. Rev Urol. 2016; 18(3):123-132.

· Dall’Era MA, Maddala T, Polychronopoulos L, Gallagher JR, Febbo PG, and Denes BS. Utility of the Oncotype DX® Prostate Cancer Assay in Clinical Practice for Treatment Selection in Men Newly Diagnosed with Prostate Cancer: A Retrospective Chart Review Analysis. Urology Practice. 2015;2(6):343-348.

· Eure G, Germany R, Given R, Lu R, Shnidel AW, Rothney M, et al. Use of a 17-Gene Prognostic Assay in Contemporary Urologic Practice: Results of an Interim Analysis in an Observational Cohort. Urology. 2017;107:67-75.

· Lynch JA, Rothney MP, Salup RR, Ercole CE, Mathur SC, duch*ene DA, et al. Improving Risk Stratification Among Veterans Diagnosed With Prostate Cancer: Impact of the 17-Gene Genomic Prostate Score Assay. Am J Manag Care. 2017;24(1 Suppl):S4-S10.

· Murphy AB, Abern MR, Liu L, Wang H, Hollowell CMP, Sharifi R, Vidal P, et al. Impact of a Genomic Test on Treatment Decision in a Predominantly African American Population With Favorable-Risk Prostate Cancer: A Randomized Trial. J Clin Oncol. 2021;39(15):1660-1670.

· Brooks MA, Thomas L, Magi-Galluzzi C, Li J, Crager MR, Lu R et al. GPS assay association with long-term cancer outcomes: twenty-year risk of distant metastasis and prostate cancer-specific mortality. JCO Precis Oncol. 2021;5:PO.20.00325.

· Brooks MA, Thomas L, Magi-Galluzzi C, Li J, Crager MR, Lu R et al. Validating the association of adverse pathology with distant metastasis and prostate cancer mortality 20-years after radical prostatectomy. Urol Oncol. 2022;40(3):104.e1-104.e7.

· Covas Moschovas M, Chew C, Bhat S, Sandri M, Rogers T, Dell’Oglio P, et al. Association Between Oncotype DX Genomic Prostate Score and Adverse Tumor Pathology After Radical Prostatectomy. Eur Urol Focus. 2022;8(2):418-424.

· Cullen J, Rosner IL, Brand TC, Zhang N, Tsiatis AC, Moncur J, et al. A biopsy-based 17-gene genomic prostate score predicts recurrence after radical prostatectomy and adverse surgical pathology in a racially diverse population of men with clinically low- and intermediate-risk prostate cancer. Eur Urol. 2015;69(1):123-131.

· Cullen J, Kuo HC, Shan J, Aboushwareb T, and Van Den Eeden SK. The 17-gene genomic prostate score test as a predictor of outcomes in men with unfavorable intermediate-risk prostate cancer. Urology. 2020;143:103-111.

· Cullen J, Lynch JA, Klein EA, Van Den Eeden SK, Carroll PR, Mohler JL, et al. Multicenter Comparison of 17-Gene Genomic Prostate Score as a Predictor of Outcomes in African American and Caucasian American Men with Clinically Localized Prostate Cancer. J Urol. 2021;205(4):1047-1054.

· Eggener S, Karsh LI, Richardson T, Shindel AW, Lu R, Rosenberg A et al. A 17-gene panel for prediction of adverse prostate cancer pathologic features: prospective clinical validation and utility. Urology. 2019;126:76-82.

· Helfand BT, Paterakos M, Wang CH, Talaty P, Abran J, Bennett J et al. The 17-gene Genomic Prostate Score assay as a predictor of biochemical recurrence in men with intermediate and high-risk prostate cancer. PLoS One. 2022;17(9):e0273782.

· Helfand BT, Paterakos M, Wang CH, Talaty P, Abran J, Bennett J et al. The 17-gene Genomic Prostate Score assay as a predictor of biochemical recurrence in men with intermediate and high-risk prostate cancer. PLoS One. 2022;17(9):e0273782.

· Janes JL, Boyer MJ, Bennett JP, Thomas VM, De Hoedt AM, Edwards DK, et al. Prognostic for outcomes after primary external beam radiation therapy in men with clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 2023;115(1):120-131.

· Klein EA, Cooperberg MR, Magi-Galluzzi C, Simko JP, Falzarano SM, Maddala T et al. A 17-gene assay to predict prostate cancer aggressiveness in the context of Gleason grade heterogeneity, tumor multifocality, and biopsy undersampling. Eur Urol. 2014;66(3):550–560.

· Kornberg Z, Cowan JE, Westphalen AC, Cooperberg MR, Chan JM, Zhao S, et al. Genomic prostate score, PI-RADS version 2 and progression in men with prostate cancer on active surveillance. J Urol. 2019;201:300-307.

· Leapman MS, Westphalen AC, Ameli N, Lawrence HJ, Febbo PG, Cooperberg M, et al. Association between a 17-gene genomic prostate score and multi-parametric prostate MRI in men with low and intermediate-risk prostate cancer. PLoS One. 2017;12(10):e0185535.

· Lin D, Zheng Y, McKenney JK, Brown MD, Lu R, Crager M, et al. 17-gene genomic prostate score test results in the Canary Prostate Active Surveillance Study (PASS) cohort. J Clin Oncol. 2020;38(14):1549-1557.

· Magi-Galluzzi C, Isharwal S, Falzarano SM, Tsiatis A, Dee A, Maddala T et al. The 17-gene genomic prostate score assay predicts outcomes after radical prostatectomy independent of PTEN status. Urology. 2018;121:132-138.

· Murphy AB, Carbunaru S, Nettey OS, Gornbein C, Dixon MA, Macias V, et al. A 17-Gene Panel Genomic Prostate Score Has Similar Predictive Accuracy for Adverse Pathology at Radical Prostatectomy in African American and European American Men. Urology. 2020; 142:166-173.

· Salmasi A, Said J, Shindel AW, Khoshnoodi P, Felker ER, Sisk Jr AE et al. A 17-gene Genomic Prostate Score assay provides independent information on adverse pathology in the setting of combined multiparametric magnetic resonance fusion-targeted and systematic prostate biopsy. J Urol. 2018;200(3):564-572.

· Van Den Eeden SK, Lu R, Zhang N, Queensberry Jr CP, Shan J, Han JS, et al. A biopsy-based 17-gene genomic prostate score as a predictor of metastases and prostate cancer death in surgically treated men with clinically localized disease. Eur Urol. 2017;73(1):129-138.

MDxHealth fait le point sur ses activités - mdxhealth (2024)

FAQs

What is the MDx test for prostate cancer? ›

SelectMDx is a urine-based test based on prostate cancer genomic biomarkers HOXC6 and DLX1, which together have a 76% sensitivity (reliability) for detecting a prostate cancer that is aggressive enough (Gleason score of 7 or greater) to require treatment.

What is the my prostate score test? ›

MPS2 is a urine test designed to predict the presence of clinically significant prostate cancer (Grade Group ≥2 or Gleason score ≥7) by analyzing a comprehensive array of 18 unique gene transcripts. Among the transcripts, the test's foundation is the novel gene fusion, T2:ERG.

What is confirm MDx? ›

The Confirm mdx test will help to determine if you are at risk for undetected prostate cancer. The test examines your biopsy tissue at a DNA level to detect cancer-related changes that cannot be seen during a standard microscopic evaluation.

Does MDxHealth add hereditary prostate cancer genetic test to prostate cancer offering? ›

With a simple saliva sample, the new comprehensive hereditary prostate cancer test offering provides insights into a patient's risk of developing cancer, disease progression, and response to prostate cancer therapies.

What is considered high PSA for prostate cancer? ›

In general, however, the likelihood of prostate cancer increases along with blood PSA levels. If a relatively high PSA level (approximately 4.0 ng/mL or above) is detected, most physicians recommend repeat testing supplemented by other noninvasive tests, such as an MRI scan, rather than immediately ordering a biopsy.

What is the most reliable test for prostate cancer? ›

A prostate biopsy is one of the most accurate ways to diagnose prostate cancer.

What level of PSA is alarming? ›

Decoding a PSA Test

In general: For men in their 40s and 50s: A PSA score greater than 2.5 ng/ml is considered abnormal. The median PSA for this age range is 0.6 to 0.7 ng/ml. For men in their 60s: A PSA score greater than 4.0 ng/ml is considered abnormal.

Do you get hard during a prostate exam? ›

Note: Some patients may develop an erection during the examination; this is completely normal as erections can result from anxiety, temperature changes and a reflex to touch, in addition to sexual arousal.

How high can PSA levels go with prostatitis? ›

Significantly elevated PSA levels > 1,000 ng/mL can be observed in non-cancerous prostatic conditions such as acute prostatitis among others.

What is MDX genetic testing? ›

1 week ago. Select mdx is a non-invasive urine test that—when combined with a patient's clinical risk factors—can help determine if a patient is at higher or lower risk for prostate cancer, and which men can safely avoid biopsy.

Is ConfirmMDX fda approved? ›

ConfirmMDX is not yet FDA approved but is in use as a supplement to traditional diagnostic such as a biopsy.

What is the Prolaris prostate test? ›

Prolaris is a genomic test that analyzes changes in 46 genes in prostate biopsy tissue. It generates a risk score to help predict the likelihood of disease progression in men with localized prostate cancer.

What type of prostate cancer is hereditary? ›

Most prostate cancers are not associated with a hereditary predisposition, but prostate cancers that have spread or are more aggressive are more likely to be associated with a hereditary predisposition. The aggressiveness of prostate cancer is determined by what is called the Gleason score.

How can you prevent hereditary prostate cancer? ›

There's no proven prostate cancer prevention strategy. But you may reduce your risk of prostate cancer by making healthy choices, such as exercising and eating a healthy diet. If you're concerned about your risk of prostate cancer, you may be interested in prostate cancer prevention.

Is there a family link for prostate cancer? ›

Men who have a close relative with prostate cancer may be twice as likely to develop the disease, while those with 2 or more relatives may be nearly 4 times as likely to be diagnosed.

What are the three tests for prostate cancer? ›

Tests for prostate cancer
  • a digital rectal examination.
  • a PSA blood test.
  • scans.
  • taking a sample of your prostate gland called a biopsy.
Apr 7, 2022

What is the new test for prostate cancer? ›

A new urine test that measures 18 genes associated with prostate cancer provides higher accuracy for detecting clinically significant cancers than PSA and other existing biomarker tests, according to a study published April 18 in JAMA Oncology.

What is the best tumor marker for prostate cancer? ›

Kallikreins. The human tissue kallikrein KLK gene locus consists of 15 genes on chromosome 19q13-4 [12]. The best known of these genes is kallikrein 3 (KLK3), also known as prostate-specific antigen (PSA), that is a widely used clinical tumour marker in serum for detection and monitoring of prostate cancer progression.

What is the score on the ExoDx prostate test? ›

The ExoDx Prostate Test, or EPI is a risk assessment tool. A score below 15.6 indicates a lower risk of high-grade prostate cancer (≥GG2) with a sensitivity of 92.0% and a negative predictive value (NPV) of 91.3%. A score above 15.6 indicates an increasing risk of high-grade prostate cancer.

References

Top Articles
Latest Posts
Article information

Author: Horacio Brakus JD

Last Updated:

Views: 5986

Rating: 4 / 5 (51 voted)

Reviews: 82% of readers found this page helpful

Author information

Name: Horacio Brakus JD

Birthday: 1999-08-21

Address: Apt. 524 43384 Minnie Prairie, South Edda, MA 62804

Phone: +5931039998219

Job: Sales Strategist

Hobby: Sculling, Kitesurfing, Orienteering, Painting, Computer programming, Creative writing, Scuba diving

Introduction: My name is Horacio Brakus JD, I am a lively, splendid, jolly, vivacious, vast, cheerful, agreeable person who loves writing and wants to share my knowledge and understanding with you.